Journal article
A. Naik, Eric R. Kuhn, Kenneth T. Lewis, Keith M. Kokotovich, K. Maddipati, Xuequn Chen, Heinrich Hörber, D. Taatjes, J. Potoff, B. Jena
2018
2018
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APA
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Naik, A., Kuhn, E. R., Lewis, K. T., Kokotovich, K. M., Maddipati, K., Chen, X., … Jena, B. (2018). Mechanism of Membrane Biogenesis.
Chicago/Turabian
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Naik, A., Eric R. Kuhn, Kenneth T. Lewis, Keith M. Kokotovich, K. Maddipati, Xuequn Chen, Heinrich Hörber, D. Taatjes, J. Potoff, and B. Jena. “Mechanism of Membrane Biogenesis” (2018).
MLA
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Naik, A., et al. Mechanism of Membrane Biogenesis. 2018.
BibTeX Click to copy
@article{a2018a,
title = {Mechanism of Membrane Biogenesis},
year = {2018},
author = {Naik, A. and Kuhn, Eric R. and Lewis, Kenneth T. and Kokotovich, Keith M. and Maddipati, K. and Chen, Xuequn and Hörber, Heinrich and Taatjes, D. and Potoff, J. and Jena, B.}
}
Abstract
Biological membrane in addition to delimiting the cell and its intracellular compartments, govern a wide range of life processes including ion transport, cell division, development, growth, and migration. The addition of new membrane to existing cellular membranes may involve fusion of preformed proteoliposomes and or the incorporation of intracellular free lipids and proteins. It is reported that supported lipid bilayers with adhered lipid vesicles when laterally stretched, expand due to fusion of the adhered vesicles. Mathematical modeling of the plasma membrane suggests trafficking of lipids into stretched membranes to relieve tension. Cell swelling has been reported during mitosis and mechanical forces are implicated in morphogenesis and development. However, the process of addition of new membrane to preexisting membranes in live cells is poorly understood. Here we report in live cells, that in addition to membrane stretch, composition of the existing membrane dictates membrane growth through the selective incorporation of both proteins and lipids.